Search results for "Crepis sancta"

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Cytotoxic eudesmane sesquiterpenes from Crepis sancta

2019

Abstract Chemical exploration of Crepis sancta (L.) Bornm. (Asteraceae) aerial parts afforded two new eudesmane sesquiterpenes (1 and 2) together with three known congeners (3-5) and two known methylated flavonoids (6 and 7). Structure elucidation of the new compounds was unambiguously performed based on HRESIMS, 1D and 2D NMR spectroscopic analyses. All isolated compounds were subjected to an in vitro cytotoxicity assay against mouse lymphoma (L5178Y) cells, revealing moderate activities with IC50 ranging from 7.9 to 21.0 μM.

biology010405 organic chemistryStereochemistryChemistryMouse LymphomaIn vitro cytotoxicityPlant ScienceAsteraceaebiology.organism_classification01 natural sciencesBiochemistry0104 chemical sciences010404 medicinal & biomolecular chemistryCytotoxic T cellCrepis sanctaAgronomy and Crop ScienceTwo-dimensional nuclear magnetic resonance spectroscopyBiotechnologyPhytochemistry Letters

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